Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
ENRIGHT PATRICK G
   2. Issuer Name and Ticker or Trading Symbol
Jazz Pharmaceuticals plc [JAZZ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
5TH FL, WATERLOO EXCHANGE, WATERLOO RD		 3. Date of Earliest Transaction (Month/Day/Year)
12/11/2017
(Street)

DUBLIN 4, L2 		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Ordinary Shares 12/11/2017   M(1)   4,500 A $ 46.83 20,839 (2) D  
Ordinary Shares 12/11/2017   M(1)   4,500 A $ 81.76 25,339 D  
Ordinary Shares 12/11/2017   S(1)   800 D $ 138.145 (3) 24,539 D  
Ordinary Shares 12/11/2017   S(1)   5,358 D $ 139.5616 (4) 19,181 D  
Ordinary Shares 12/11/2017   S(1)   2,842 D $ 140.4977 (5) 16,339 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (right to buy) $ 46.83 12/11/2017   M(1)     4,500   (6) 08/08/2022 Ordinary Shares 4,500 $ 0 0 D  
Non-employee director stock option (7) $ 81.76 12/11/2017   M(1)     4,500   (8) 08/07/2023 Ordinary Shares 4,500 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
ENRIGHT PATRICK G
5TH FL, WATERLOO EXCHANGE
WATERLOO RD
DUBLIN 4, L2 		   X      

Signatures

 By: /s/Peter A Christou, as attorney in fact For: Patrick G Enright   12/13/2017
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.
(2) Includes 14,974 shares received as a pro rata liquidating distribution from Longitude Venture Partners, L.P. ("Longitude Venture") and Longitude Capital Associates, L.P. ("Longitude Capital") to their respective partners. In prior reports, the Reporting Person reported indirect ownership of the Issuer's securities held by Longitude Venture and Longitude Capital but disclaimed beneficial ownership except to the extent of his pecuniary interest therein. The Reporting Person is a managing member of Longitude Capital Partners, LLC, the general partner of each of Longitude Venture and Longitude Capital.
(3) Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $137.8000 to $138.6800. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.
(4) Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $139.1000 to $140.0800. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.
(5) Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $140.1700 to $141.1000. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.
(6) This non-qualified stock option was granted on August 9, 2012 and vested over a period of one year from the grant date. The options were fully vested as of August 9, 2013.
(7) This Security is a non-qualified stock option (right to buy).
(8) This non-qualified stock option was granted on August 8, 2013 and vested over a period of one year beginning on September 1, 2013. The options were fully vested as of August 1, 2014.

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