Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
CHL Medical Partners II, L.P.
   2. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O GREGORY M. WEINHOFF, 1055 WASHINGTON BLVD.		 3. Date of Earliest Transaction (Month/Day/Year)
06/05/2007
(Street)

STAMFORD, CT 06901		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/05/2007   C   1,850,540 A (1) 1,975,456 D  
Common Stock 06/05/2007   C   124,683 A (1) 2,108,554 I By CHL Medical Partners II Side Fund, L.P. (2)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Convertible Preferred Stock (1) 06/05/2007   C     83,278 04/15/2002   (1) Common Stock 83,278 (1) $ 0 0 D  
Series A Convertible Preferred Stock (1) 06/05/2007   C     5,611 04/15/2002   (1) Common Stock 5,611 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)
Series B Convertible Preferred Stock (1) 06/05/2007   C     734,803 05/04/2004   (1) Common Stock 734,803 (1) $ 0 0 D  
Series B Convertible Preferred Stock (1) 06/05/2007   C     49,509 05/04/2004   (1) Common Stock 49,509 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)
Series B Convertible Preferred Stock (1) 06/05/2007   C     11,182 04/18/2006   (1) Common Stock 11,182 (1) $ 0 0 D  
Series B Convertible Preferred Stock (1) 06/05/2007   C     753 04/18/2006   (1) Common Stock 753 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (1)
Series C Convertible Preferred Stock (1) 06/05/2007   C     247,850 08/16/2005   (1) Common Stock 247,850 (1) $ 0 0 D  
Series C Convertible Preferred Stock (1) 06/05/2007   C     16,669 08/16/2005   (1) Common Stock 16,699 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)
Series C Convertible Preferred Stock (1) 06/05/2007   C     247,850 04/17/2006   (1) Common Stock 247,850 (1) $ 0 0 D  
Series C Convertible Preferred Stock (1) 06/05/2007   C     16,669 04/17/2006   (1) Common Stock 16,699 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)
Series D Convertible Preferred Stock (1) 06/05/2007   C     96,233 09/13/2006   (1) Common Stock 96,233 (1) $ 0 0 D  
Series D Convertible Preferred Stock (1) 06/05/2007   C     6,484 09/13/2006   (1) Common Stock 6,484 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)
Series D Convertible Preferred Stock (1) 06/05/2007   C     96,233 03/09/2007   (1) Common Stock 96,233 (1) $ 0 0 D  
Series D Convertible Preferred Stock (1) 06/05/2007   C     6,484 03/09/2007   (1) Common Stock 6,484 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)
Series A Convertible Preferred Stock (1) 06/05/2007   C     333,111 07/15/2002   (1) Common Stock 333,111 (1) $ 0 0 D  
Series A Convertible Preferred Stock (1) 06/05/2007   C     22,444 07/15/2002   (1) Common Stock 22,444 (1) $ 0 0 I By CHL Medical Partners II Side Fund, L.P. (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
CHL Medical Partners II, L.P.
C/O GREGORY M. WEINHOFF
1055 WASHINGTON BLVD.
STAMFORD, CT 06901		     X    

Signatures

 CHL Medical Partners II, L.P., By: Collinson, Howe & Lennox II, LLC, its General Partner, By: /s/ Gregory M. Weinhoff   06/06/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each of the Series A Convertible Preferred Stock, the Series B Convertible Preferred Stock, the Series C Convertible Preferred Stock and the Series D Convertible Preferred Stock automatically converted into Amicus Therapeutics, Inc. common stock on an one-for one basis upon the closing of Amicus Therapeutics, Inc.'s initial public offering on June 5, 2007.
(2) These shares are owned by CHL Medical Partners II Side Fund, L.P., which is under common control with CHL Medical Partners II, L.P. Collinson, Howe & Lennox II, LLC serves as the sole general partner of CHL Medical Partners II Side Fund, L.P. and CHL Medical Partners II, L.P. and is the indirect beneficial owner of these shares. CHL Medical Partners II, L.P. disclaims beneficial ownership of such shares except to the extent of its pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of section 16 or for any other purpose.

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