FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person *   Crowley John F 2. Date of Event Requiring Statement (Month/Day/Year) 05/30/2007 3. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [FOLD] (Last) (First) (Middle) C/O AMICUS THERAPEUTICS, INC., 6 CEDAR BROOK DRIVE 4. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director __X__ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President & CEO 5. If Amendment, Date Original Filed(Month/Day/Year) (Street) CRANBURY, NJ 08512 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5) Common Stock 13,333 (1) I By MPAJ, LLC Common Stock 60,000 (2) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust Common Stock 73,333 (3) I By John F. Crowley 2007 Grantor Retired Annuity Trust

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Employee Stock Option (right to buy)	  (4)	01/06/2015	Common Stock	158,666	$ 0.638	D	Â
Employee Stock Option (right to buy)	  (5)	08/17/2014	Common Stock	16,490	$ 0.638	D	Â
Employee Stock Option (right to buy)	  (6)	10/20/2015	Common Stock	100,000	$ 5.33	D	Â
Employee Stock Option (right to buy)	  (7)	02/28/2016	Common Stock	280,000	$ 5.33	D	Â
Employee Stock Option (right to buy)	  (8)	04/25/2017	Common Stock	200,000	$ 13.43	D	Â

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Crowley John F C/O AMICUS THERAPEUTICS, INC. 6 CEDAR BROOK DRIVE CRANBURY, NJ 08512	  X	  X	  President & CEO	Â

Signatures

/s/ Douglas A. Branch, Attorney-in-fact		05/30/2007
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	These shares are held by MPAJ, LLC.
(2)	These shares are held by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust. Mr. Crowley disclaims beneficial ownership of the shares held by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of section 16 or for any other purpose.
(3)	These shares are held by the John F. Crowley 2007 Grantor Retained Annuity Trust.
(4)	These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on January 3, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 6,247 shares, beginning on February 3, 2006, with the final installment of 6,231 shares becoming exercisable on January 3, 2009.
(5)	These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on August 17, 2005. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 458 shares, beginning on September 1, 2005, with the final installment of 460 shares becoming exercisable on August 1, 2008.
(6)	These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on October 20, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 20,084 shares, beginning on November 1, 2006, with the final installment of 20,060 shares becoming exercisable on October 1, 2009.
(7)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vest on February 28, 2007. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 5,834 shares, beginning on March 1, 2007, with the final installment of 5,810 shares becoming exercisable on February 1, 2010.
(8)	These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on April 25, 2008. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 4,167 shares, beginning on May 1, 2008, with the final installment of 4,155 shares becoming exercisable on April 1, 2011.

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