UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549

                                    FORM 13F

                              FORM 13F COVER PAGE


                 Report for the Quarter Ended December 31, 2010



                          AMERICAN FINANCIAL GROUP, INC.
                 One East Fourth Street, Cincinnati, Ohio 45202
     -------------------------------------------------------------------------
     (Name and Address of Institutional Investment Manager Filing this Report)


                         Form 13F File Number:  28-4389


The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.

                                 Robert H. Ruffing
                     	   Vice President and Controller
                                   (513) 579-2144
                -----------------------------------------------
                (Name, Title and Phone Number of Person Signing
                 this Report on Behalf of Reporting Manager)



Signature:

/s/Robert H. Ruffing                  Cincinnati, Ohio         February 9, 2011
-------------------------------
Robert H. Ruffing
Vice President and Controller


Report Type:
     [X]  13F HOLDINGS REPORT.
     [ ]  13F NOTICE.
     [ ]  13F COMBINATION REPORT.














                            FORM 13F SUMMARY PAGE
                            ---------------------




Number of Other Included Managers:                         1
                                                      -----------

Form 13F Information Table Entry Total:                   76
                                                      -----------

Form 13F Information Table Value Total (thousands):     $544,562
                                                      -----------



Name and 13F file numbers of all Institutional Investment Managers with respect
to which this schedule is filed (other than American Financial Group, Inc.):

    Number    13F File Number         Name of Subsidiary
    ------    ---------------         ------------------------------------

       1.          28-498             Great American Insurance Company






































                                                       FORM 13F INFORMATION TABLE


                                                             Column 4:   Column 5:                               Column 8:
                                   Column 2:                  Market     Shares or    Column 6: Column 7:    Voting Authority
        Column 1:                  Title of       Column 3:    Value     Principal   Investment    Other ---------------------------
     Name of Issuer                  Class          CUSIP     (000's)      Amount    Discretion Managers    Sole    Shared    None
     --------------             ---------------- ----------- ---------  ------------ ---------- -------- ---------- ------ ---------


HOLDINGS OF GREAT AMERICAN INSURANCE COMPANY
--------------------------------------------
                                                                                                 
AMERICAN RAILCAR INDS INC             COM        02916P 10 3     1,505      68,000SH   Defined     1         68,000
ANWORTH MORTGAGE ASSET CP             COM        037347 10 1       875     125,000SH   Defined     "        125,000
BANK OF AMERICA CORPORATION           COM        060505 10 4     1,442     108,120SH   Defined     "        108,120
CALAMP CORP                           COM        128126 10 9       439     139,750SH   Defined     "        139,750
CHEVRON CORP NEW                      COM        166764 10 0    11,525     126,300SH   Defined     "        126,300
CITIGROUP INC                         COM        172967 10 1     2,838     600,000SH   Defined     "        600,000
COCA COLA CO                          COM        191216 10 0    11,345     172,500SH   Defined     "        172,500
COMCAST CORP NEW                     CL A        20030N 10 1     8,865     403,500SH   Defined     "        403,500
DELTA AIR LINES INC DEL             COM NEW      247361 70 2       460      36,473SH   Defined     "         36,473
DISH NETWORK CORP                    CL A        25470M 10 9       741      37,675SH   Defined     "         37,675
ECHOSTAR CORP                        CL A        278768 10 6       619      24,786SH   Defined     "         24,786
ELLINGTON FINANCIAL LLC               COM        288522 30 3     6,672     300,000SH   Defined     "        300,000
FLAGSTAR BANCORP INC                COM NEW      337930 50 7        27      16,500SH   Defined     "         16,500
FULL HOUSE RESORTS INC		      COM        359678 10 9       120      35,331SH   Defined     "         35,331
HEINZ H J CO                          COM        423074 10 3    10,275     207,750SH   Defined     "        207,750
INSTEEL INDUSTRIES INC                COM        45774W 10 8       307      24,609SH   Defined     "         24,609
INTEL CORP                            COM        458140 10 0    10,704     509,000SH   Defined     "        509,000
INTERNATIONAL BUSINESS MACHS          COM        459200 10 1    11,117      75,750SH   Defined     "         75,750
JPMORGAN CHASE & CO                   COM        46625H 10 0     5,303     125,000SH   Defined     "        125,000
JOHNSON & JOHNSON                     COM        478160	10 4     9,958     161,000SH   Defined	   "        161,000
KELLOGG CO                            COM        487836 10 8    11,179     218,850SH   Defined     "        218,850
KIMBERLY CLARK CORP                   COM        494368 10 3    11,347     180,000SH   Defined     "        180,000
KRAFT FOODS INC                      CL A        50075N 10 4    14,912     473,250SH   Defined     "        473,250
LOCKHEED MARTIN CORP                  COM        539830 10 9     5,278      75,500SH   Defined     "         75,500
MYR GROUP INC DEL                     COM        55405W 10 4     8,077     384,615SH   Defined     "        384,615
MCDONALDS CORP                        COM        580135 10 1    10,708     139,500SH   Defined     "        139,500
MERCK & CO INC NEW                    COM        58933Y 10 5     9,046     251,000SH   Defined     "        251,000
MICROSOFT CORP                        COM        594918 10 4    11,206     401,500SH   Defined     "        401,500
MOTRICITY INC                         COM        620107 10 2     1,532      82,525SH   Defined     "         82,525
NATIONAL INTERSTATE CORP              COM        63654U 10 0   218,382  10,200,000SH   Defined     "     10,200,000
O CHARLEYS INC                        COM        670823 10 3       212      29,500SH   Defined     "         29,500
OMEROS CORP                           COM        682143 10 2       841     102,040SH   Defined     "        102,040
PATTERSON UTI ENERGY INC              COM        703481 10 1       862      40,000SH   Defined     "         40,000
PEPSICO INC                           COM        713448 10 8     9,803     150,050SH   Defined     "        150,050
PFIZER INC                            COM        717081 10 3     7,319     418,000SH   Defined     "        418,000
RAYTHEON CO                         COM NEW      755111 50 7     3,499      75,500SH   Defined     "         75,500
3M CO                                 COM        88579Y 10 1    10,054     116,500SH   Defined     "        116,500
TIME WARNER INC                     COM NEW      887317 30 3       280       8,716SH   Defined     "          8,716
TORTOISE ENERGY CAP CORP              COM        89147U 10 0       717      25,800SH   Defined     "         25,800
VIRGIN MEDIA INC                      COM        92769L 10 1    20,098     737,807SH   Defined     "        737,807
WALGREEN CO                           COM        931422 10 9     9,604     246,500SH   Defined     "        246,500
WELLS FARGO & CO NEW                  COM        949746 10 1     5,578     180,000SH   Defined     "        180,000






HOLDINGS OF OTHER ENTITIES
EACH HAVING LESS THAN
$100 MILLION IN 13F SECURITIES
------------------------------
ACE LTD                               SHS        H0023R 10 5     3,922      63,000SH    Sole                 63,000
AMERICAN RAILCAR INDS INC             COM        02916P 10 3     1,496      67,581SH   Defined               67,581
ANWORTH MORTGAGE ASSET CP             COM        037347 10 1       875     125,000SH   Defined              125,000
BANK OF AMERICA CORPORATION           COM        060505 10 4     4,315     323,480SH   Defined              323,480
BERKLEY W R CORP                      COM        084423 10 2     3,203     117,000SH    Sole                117,000
CALAMP CORP                           COM        128126 10 9       442     140,750SH   Defined              140,750
CHUBB CORP                            COM        171232 10 1     4,234      71,000SH    Sole                 71,000
DELTA AIR LINES INC DEL             COM NEW      247361 70 2       495      39,306SH   Defined               39,306
DEX ONE CORP                          COM        25212W 10 0        80      10,772SH   Defined               10,772
DISH NETWORK CORP                    CL A        25470M 10 9     1,111      56,512SH   Defined               56,512
EATON VANCE TAX MNG GBL DV E          COM        27829F 10 8       421      40,000SH   Defined     1         40,000
ECHOSTAR CORP                        CL A        278768 10 6       928      37,179SH   Defined               37,179
ELLINGTON FINANCIAL LLC               COM        288522 30 3    10,008     450,000SH   Defined              450,000
FLAGSTAR BANCORP INC                COM NEW      337930 50 7        27      16,500SH   Defined               16,500
FULL HOUSE RESORTS INC		      COM        359678 10 9       107      31,617SH   Defined               31,617
INSTEEL INDUSTRIES INC                COM        45774W 10 8       277      22,216SH   Defined               22,216
ISHARES TR                        MSCI EAFE IDX  464287 46 5     2,503      43,000SH   Defined     1         43,000
ISHARES TR                       DJ US TELECOMM  464287 71 3       223       9,550SH   Defined     "          9,550
KEYCORP NEW                           COM        493267 10 8       462      52,222SH   Defined     "         52,222
MANAGED HIGH YIELD PLUS FD I          COM        561911 10 8        22      10,000SH   Defined     "         10,000
MERCK & CO INC NEW                    COM        58933Y 10 5       721      20,000SH   Defined               20,000
MOTRICITY INC                         COM        620107 10 2     2,299     123,787SH   Defined              123,787
O CHARLEYS INC                        COM        670823 10 3       322      44,654SH   Defined               44,654
OMEROS CORP                           COM        682143 10 2     1,261     153,061SH   Defined              153,061
PATTERSON UTI ENERGY INC              COM        703481 10 1       862      40,000SH   Defined               40,000
PFIZER INC                            COM        717081 10 3       350      20,000SH   Defined               20,000
POWERSHARES ETF TRUST            DYNAMIC MKT PT  73935X 10 4     1,074      24,400SH   Defined     1         24,400
POWERSHARES ETF TRUST            HI YLD EQ DVDN  73935X 30 2       189      21,300SH   Defined     "         21,300
SPDR S&P 500 ETF TR                 TR UNIT      78462F 10 3     5,533      44,000SH   Defined     "         44,000
SELECT SECTOR SPDR TR            SBI MATERIALS   81369Y 10 0       217       5.660SH   Defined     "          5,660
SELECT SECTOR SPDR TR            SBI CONS STPLS  81369Y 30 8     1,028      35,060SH   Defined     "         35,060
SELECT SECTOR SPDR TR            SBI INT-UTILS   81369Y 88 6       235       7,500SH   Defined     "          7,500
TORTOISE ENERGY CAP CORP              COM        89147U 10 0     2,385      85,900SH   Defined               85,900
VIRGIN MEDIA INC                      COM        92769L 10 1    27,264   1,000,888SH   Defined            1,000,888


                                                             ----------
                                 REPORT TOTAL                 $544,562
                                                             ==========