AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON APRIL 26, 2001
                                                            Registration No. 33-

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549
    -----------------------------------------------------------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                            O'Reilly Automotive, Inc.
--------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in its Charter)

           Missouri                                         44-0618012
----------------------------------          ------------------------------------
(State or Other Jurisdiction of             (I.R.S. Employer Identification No.)
 Incorporation or Organization)

       233 South Patterson
      Springfield, Missouri                                   65802
----------------------------------          ------------------------------------
(Address of Principal Executive                             (Zip Code)
 Offices)

            O'Reilly Automotive, Inc. Profit Sharing and Savings Plan
--------------------------------------------------------------------------------
                            (Full Title of the Plan)

                                David E. O'Reilly
                      President and Chief Executive Officer
                            O'Reilly Automotive, Inc.
                               233 South Patterson
                           Springfield, Missouri 65802
--------------------------------------------------------------------------------
                     (Name and Address of Agent for Service)

                                 (417) 862-6708
--------------------------------------------------------------------------------
                     (Telephone Number, Including Area Code,
                              of Agent for Service)

                        Copies of All Correspondence to:

                             Robert H. Wexler, Esq.
                         Gallop, Johnson & Neuman, L.C.
                             Interco Corporate Tower
                              101 South Hanley Road
                            St. Louis, Missouri 63105

================================================================================

                         CALCULATION OF REGISTRATION FEE

================================================================================
 Title of                       Proposed          Proposed
securities      Amount       maximum offering     maximum            Amount of
  to be         to be         offering price      aggregate         registration
registered   registered(1)     per share(2)     offering price         fee
--------------------------------------------------------------------------------

Common Stock
$.01 par          1,000,000      $21.04          $21,040,000          $5,260
================================================================================


(1)  Represents  maximum number of additional shares of Common Stock (1,000,000)
     available for issuance under the O'Reilly  Automotive,  Inc. Profit Sharing
     and Savings Plan. The Registrant  previously  filed with the Securities and
     Exchange  Commission on January 10, 1994, a Registration  Statement on Form
     S-8 (Reg. No. 33-73892) relating to securities offered under such Plan.

(2)  Estimated solely for the purpose of calculating the registration  fee. Such
     estimate  has been  calculated  in  accordance  with Rule 457(h)  under the
     Securities  Act of 1933,  and is based upon the average of the high and low
     prices  per  share of the  Registrant's  Common  Stock as  reported  by the
     National  Association of Securities  Dealers Automated  Quotation  National
     Market System on April 23, 2001.


Pursuant to Rule 416(a) of the  Securities  Act of 1933, as amended (the "Act"),
this registration  statement shall be deemed to cover additional shares that may
be issued to adjust the number of shares issued pursuant to the Plan as a result
of any future stock split,  stock  dividend or other  similar  adjustment of the
outstanding  shares of common  stock of O'Reilly  Automotive,  Inc. In addition,
pursuant to Rule 416(c) under the Act, this  registration  statement also covers
an indeterminate amount of interests to be offered and sold pursuant to the Plan
described herein.




                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

     The Registrant previously filed with the Securities and Exchange Commission
(the  "Commission")  on January 10, 1994 a  registration  statement  on Form S-8
(Registration  No. 33-73892)  relating to securities  offered under the O'Reilly
Automotive,  Inc.  Profit  Sharing  and  Savings  Plan.  The  contents  of  such
previously  filed  registration  statements  on  Form  S-8,  including  exhibits
thereto,  are incorporated herein by reference,  except to the extent superseded
or modified by the specific information set forth below or the specific exhibits
attached hereto.

Item 3.  Incorporation of Documents by Reference

         The following documents filed by the Registrant with the Securities and
Exchange Commission are incorporated herein by reference:

     (a) The  Registrant's  latest annual report on Form 10-K filed  pursuant to
Section 13 or 15(d) of the  Securities  Exchange  Act of 1934,  as amended  (the
"Exchange Act");

     (b) All other  reports  filed by the  Registrant  pursuant to Section 13 or
15(d) of the Exchange Act since the end of the fiscal year covered by the annual
report referred to in (a) above; and

     (c) The description of the Registrant's  common stock which is contained in
the  Registrant's  Registration  Statement  on Form  S-1  (File  No.  33-58948),
including  any  amendment  or report  filed for the  purpose  of  updating  such
description.


     All documents  subsequently filed pursuant to Sections 13(a), 13(c), 14 and
15(d) of the Exchange  Act,  prior to the filing of a  post-effective  amendment
which  indicates  that all  securities  offered  hereby  have been sold or which
deregisters  all such securities  then remaining  unsold,  shall be deemed to be
incorporated by reference in this registration statement and to be a part hereof
from the date of filing of such documents. Any statement contained in a document
incorporated  by reference  herein and filed prior to the filing hereof shall be
deemed to be modified or superseded for purposes of this registration  statement
to the extent that a statement  contained  herein  modifies or  supersedes  such
statement,  and  any  statement  contained  herein  or  in  any  other  document
incorporated  by reference  herein shall be deemed to be modified or  superseded
for  purposes  of this  registration  statement  to the extent  that a statement
contained in any other subsequently filed document which also is incorporated by
reference  herein modifies or supersedes  such statement.  Any such statement so
modified or superseded shall not be deemed, except as so modified or superseded,
to constitute a part of this registration statement.

Item 8.  Exhibits

     The following exhibits are filed as part of this registration  statement or
incorporated by reference herein.

Exhibit
Number            Description
-------           -----------

5.1          Opinion of Gallop, Johnson & Neuman, L.C. (filed herewith).

23.1         Consent of Ernst & Young LLP (filed herewith).

23.2         Consent of Gallop, Johnson & Neuman, L.C.(included in Exhibit 5.1).

24           Power of Attorney (included on signature page of the registration
             statement).





                                   SIGNATURES

     The Registrant. Pursuant to the requirements of the Securities Act of 1933,
the registrant certifies that it has reasonable grounds to believe that it meets
all of the  requirements  for  filing  on  Form  S-8 and has  duly  caused  this
registration statement to be signed on its behalf by the undersigned,  thereunto
duly  authorized  in the city of  Springfield,  state of Missouri,  on April 26,
2001.

                             O'REILLY AUTOMOTIVE, INC.


                             By:    /s/ David E. O'Reilly
                                    --------------------------------------------
                                    David E. O'Reilly
                                    Co-Chairman of the Board and Chief Executive
                                    Officer

                                POWER OF ATTORNEY

     We, the undersigned  officers and directors of O'Reilly  Automotive,  Inc.,
hereby severally and  individually  constitute and appoint David E. O'Reilly and
Lawrence P. O'Reilly and each of them, the true and lawful  attorneys and agents
of  each  of  us to  execute  in  the  name,  place  and  stead  of  each  of us
(individually  and in any capacity  stated below) any and all amendments to this
Registration Statement on Form S-8 and all instruments necessary or advisable in
connection  therewith  and to file the same  with the  Securities  and  Exchange
Commission,  each of said  attorneys and agents to have the power to act with or
without the other and to have full power and  authority to do and perform in the
name and on behalf of each of the undersigned every act whatsoever  necessary or
advisable to be done in the premises as fully and to all intents and purposes as
any of the  undersigned  might or could do in person,  and we hereby  ratify and
confirm our  signatures  as they may be signed by our said  attorneys and agents
and each of them to any and all such amendments and instruments.

     Pursuant  to  the   requirements  of  the  Securities  Act  of  1933,  this
registration  statement  has  been  signed  by  the  following  persons  in  the
capacities and on the dates indicated.

     Name                                Title                      Date


/s/ David E. O'Reilly             Co-Chairman of the Board,       April 26, 2001
------------------------------    Chief Executive Officer
David E. O'Reilly                 and Director (principal
                                  executive officer)


/s/ Lawrence P. O'Reilly          Co-Chairman of the Board,       April 26, 2001
------------------------------    Chief Operating Officer
Lawrence P. O'Reilly              and Director


/s/ Charles H. O'Reilly, Jr.      Vice-Chairman of the Board      April 26, 2001
------------------------------    and Director
Charles H. O'Reilly, Jr.


                                  Executive Vice President      April ___ , 2001
------------------------------    and Director
Rosalie O'Reilly Wooten


/s/ Charles H. O'Reilly, Sr.      Chairman Emeritus               April 26, 2001
------------------------------    and Director
Charles H. O'Reilly, Sr.


/s/ James R. Batten               Vice-President of Finance,      April 26, 2001
------------------------------    Chief Financial Officer
James R. Batten                   and Treasurer(principal
                                  financial officer)


/s/ Joe C. Greene                 Director                       April 26, 2001
------------------------------
Joe C. Greene


/s/ Jay D. Burchfield             Director                       April 26, 2001
------------------------------
Jay D. Burchfield


                                  Director                      April ___ , 2001
------------------------------
Paul R. Lederer





                                    FORM S-8

                            O'REILLY AUTOMOTIVE, INC.

                                  EXHIBIT INDEX


Exhibit
Number     Description                                               Page


5.1        Opinion of Gallop, Johnson & Neuman, L.C....................

23.1       Consent of Ernst & Young LLP................................

23.2       Consent of Gallop, Johnson & Neuman, L.C. (included
           in Exhibit 5.1).............................................      N/A

24         Power of Attorney (included on signature page of the
           registration statement) ....................................      N/A




                                                                     EXHIBIT 5.1

                         GALLOP, JOHNSON & NEUMAN, L.C.
                                  101 S. Hanley
                            St. Louis, Missouri 63105

                                 April 26, 2001


Board of Directors
O'Reilly Automotive, Inc.
233 South Patterson
Springfield, Missouri   65802

         Re:      Registration Statement on Form S-8
                  O'Reilly Automotive, Inc. Profit Sharing and Savings Plan

Ladies and Gentlemen:

     We have served as counsel to O'Reilly  Automotive,  Inc. (the "Company") in
connection  with  the  various  legal  matters  relating  to  the  filing  of  a
registration  statement  on Form S-8 (the  "Registration  Statement")  under the
Securities Act of 1933, as amended,  and the Rules and  Regulations  promulgated
thereunder,  relating to 1,000,000  shares of common  stock of the Company,  par
value $.01 per share (the  "Shares"),  reserved for issuance in accordance  with
the O'Reilly Automotive, Inc. Profit Sharing and Savings Plan (the "Plan").

     We have examined such corporate records of the Company,  such laws and such
other information as we have deemed relevant,  including the Company's  Restated
Articles of Incorporation,  and Amended and Restated Bylaws, certain resolutions
adopted  by the  Board of  Directors  of the  Company  relating  to the Plan and
certificates  received from state officials and from officers of the Company. In
delivering this opinion, we have assumed the genuineness of all signatures,  the
authenticity  of all documents  submitted to us as originals,  the conformity to
the originals of all  documents  submitted to us as  certified,  photostatic  or
conformed  copies,  and the  correctness  of all  statements  submitted to us by
officers of the Company.

          Based upon the foregoing, the undersigned is of the opinion that:

     1.   The Company is a corporation duly  incorporated,  validly existing and
          in good standing under the laws of the State of Missouri.

     2.   The Common Stock being offered by the Company, if issued in accordance
          with the Plan,  will be  validly  issued and  outstanding  and will be
          fully paid and nonassessable.

     We consent to the use of this opinion  as an  exhibit  to the  Registration
Statement  and to the use of our  name in the  Registration  Statement.  We also
consent to your filing copies of this opinion as an exhibit to the  Registration
Statement  with  agencies of such states as you deem  necessary in the course of
complying  with the laws of such  states  regarding  the  issuance of the Shares
pursuant to the Plan.


                                          Very truly yours,

                                          /s/ GALLOP, JOHNSON & NEUMAN, L.C.

                                          GALLOP, JOHNSON & NEUMAN, L.C.






                                                                    EXHIBIT 23.1


                         Consent of Independent Auditors


We consent to the incorporation by reference in the Registration Statement (Form
S-8 No. 33-XXXXX) pertaining to the O'Reilly Automotive, Inc. Profit Sharing and
Savings Plan of O'Reilly  Automotive,  Inc. and subsidiaries of our report dated
February 23, 2001,  with respect to the  consolidated  financial  statements  of
O'Reilly  Automotive,  Inc. and  subsidiaries  incorporated  by reference in its
Annual  Report  (Form 10-K) for the year ended  December 31, 2000 filed with the
Securities and Exchange Commission.


                                                 /s/ Ernst & Young LLP



Kansas City, Missouri
April 23, 2001