UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                    ----------------------------------------

                                   FORM 8-K/A
                                 Amendment No. 1

                                 CURRENT REPORT



                     Pursuant to Section 13 or 15 (d) of the
                         Securities Exchange Act of 1934

                Date of Report - March 12, 2003 (March 11, 2003)
                        (Date of earliest event reported)


                           Hemispherx Biopharma, Inc.
             (Exact name of registrant as specified in its charter)



      Delaware                      0-27072                 52-0845822
(State or other jurisdiction   (Commission File Number)    (IRS Employer
 of incorporation)                                          Identification
                                                            Number)




     1617 JFK Boulevard                                    19103
  (Address of principal executive offices)              (Zip Code)


                            Area Code (215) 988-0080
                         (Registrant's telephone number








Item 7.       Financial Statements and Exhibits.

Seth forth below are the required  Financial  Statements and Pro Forma Financial
Information  related  to the  Registrant's  acquisition  of  certain  assets  of
Interferon Sciences, Inc. on March 11, 2003.

              (a)     Financial Statements.

The financial statements of Interferon Sciences, Inc. ("ISI") as of December 31,
2002 and 2001,  and for the three years ended  December 31, 2002 are included as
EXHIBIT 99.1 to this Form 8-K/A and are incorporated herein by reference.

              (b)     Unaudited Pro forma Financial Information.

Consolidated  Statements of Operations  for the year ended December 31, 2002 and
for the three months ended March 31, 2003.

Consolidated Balance Sheet as of March 31, 2003.






              UNAUDITED PRO FORMA CONSOLIDATED FINANCIAL STATEMENTS

On March 11, 2003, we executed two agreements  with  Interferon  Sciences,  Inc.
("ISI") to purchase certain of its assets.

In the first agreement with ISI, the Company acquired ISI's inventory of ALFERON
N  Injection(R),  and a limited  license for the  production,  manufacture  use,
marketing and sale of this product. For these assets, the Company:

i)       Issued 487,028 shares of its common stock, and
ii)      Agreed to pay ISI 6% of the net sales of the Product.

The  Company  also is required to pay ISI a service fee and pay certain of ISI's
obligation related to the product.

In the second  agreement  with ISI, ISI has agreed to sell to the Company all of
ISI's rights to the product and other assets  related to the product  including,
but not limited to, real estate and  machinery.  For these  assets,  the Company
will:  i) Issue an  additional  487,028  shares  of its  common  stock;  and ii)
Continue to pay ISI 6% of the net sales of the product

In addition,  the Company was required to satisfy three  obligations of ISI. The
Company satisfied two of these obligations,  pursuant to forbearance  agreements
with The American National Red Cross and GP Strategies Corporation, two of ISI's
creditors,  by issuing an aggregate  of 581,761  shares of common stock to these
creditors.  The third obligation is approximately  $521,000 and was secured by a
lien on the property.

The second agreement with ISI is contingent on the Company receiving appropriate
governmental  approval  for the real  estate  transaction  and ISI  stockholders
approving the transactions contemplated by the second agreement.

We will account for these transactions as a Business Combination under Statement
of  Financial  Accounting  Standards  ("SFAS") No. 141  Accounting  for Business
Combinations.

On March 12, 2003, we issued an aggregate of  $5,426,000 in principal  amount of
6% Senior  Convertible  Debentures  due  January 31,  2005 and an  aggregate  of
743,288  Warrants  to  two  investors  in  a  private  placement  for  aggregate
anticipated  gross  proceeds  of  $4,650,000.  Pursuant  to  the  terms  of  the
Debentures, $1,550,000 of the proceeds from the sale of the Debentures were held
back and were to be released to us if, and only if we acquire, within a set time
frame,  ISI's  facility,  which  is  currently  contingent  upon  receiving  the
appropriate  governmental and ISI stockholder  approval.  The Debenture  Holders
waived this requirement  and, on June 12, 2003, we received the $1,550,000.  The
Debentures mature on January 31, 2005 and bear interest at 6% per annum, payable
quarterly in cash or,  subject to  satisfaction  of certain  conditions,  common
stock. Any shares of common stock issued to the investors as payment of interest
shall be valued at 95% of the average  closing  price of the common stock during
the five consecutive  business days ending on the third business day immediately
preceding  the  applicable  interest  payment  date.  Pursuant  to the terms and
conditions  of the Senior  Convertible  Debentures,  we have  pledged all of our
assets other than intellectual property, as collateral and are subject to comply
with certain financial and negative covenants, which include but are not limited
to the repayment of principal balances upon achieving certain revenue milestone.

The  Debentures  are  convertible  at the  option of the  investors  at any time
through January 31, 2005 into shares of our common stock.  The conversion  price
under the  Debentures  is fixed at $1.46 per share,  subject to  adjustment  for
anti-dilution  protection for issuance of common stock or securities convertible
or exchangeable into common stock at a price less than the conversion price then
in effect.

The investors  also  received  Warrants to acquire at any time through March 12,
2008 an  aggregate  of  743,288  shares of common  stock at a price of $1.68 per
share.  On March 12, 2004,  the exercise price of the Warrants will reset to the
lesser of the  exercise  price then in effect or a price equal to the average of
the daily price of the common  stock  between  March 13, 2003 and March 11, 2004
(but in no event less than $1.176 per share).  The exercise price (and the reset
price)  under  the  Warrants  also  is  subject  to  similar   adjustments   for
anti-dilution protection. All of these warrants were exercised on June 25, 2003.

On June 25,  2003 the  investors  received  additional  warrants  to  acquire an
aggregate of 1,000,000  shares of common stock.  The warrants are exercisable at
$2.40 per share within five years from the date of  issuance.  On June 25, 2004,
the  exercise  price of the  Warrants  will reset to the lesser of the  exercise
price then in effect or a price  equal to the  average of the daily price of the
common stock  between June 26, 2003 and June 23, 2004 (but in no event less than
$1.68 per share).  The  exercise  price (and the reset price) under the Warrants
also is subject to similar adjustments for anti-dilution protection.

The following  unaudited Pro Forma consolidated  statement of operations for the
year ended December 31, 2002 and the three months ended March 31, 2003 have been
prepared  giving  effect to the  acquisition  of  certain  assets of ISI and the
related  funding  of  the  transaction,  by  the  Company's  senior  convertible
debentures, as if they occurred on January 1, 2002.

The following  unaudited Pro Forma consolidated  balance sheet has been prepared
as if the second  portion of the  acquisition  of certain  assets of ISI and the
related  funding  of  the  transaction,  by  the  Company's  senior  convertible
debentures, had occurred on March 31, 2003.

The unaudited pro-forma adjustments give effect to the second agreement with ISI
irrespective of the fact that the second acquisition  remains  unconsummated and
is contingent on the Company receiving the appropriate governmental approval for
the real estate to be acquired and ISI stockholders approving the transaction.

The  unaudited Pro Forma  consolidated  financial  statements  should be read in
conjuction with the notes hereto and the following:  o The Company's  historical
consolidated  financial statements and notes thereto for the year ended December
31, 2002 included
     in the Company's Annual Report on Form 10-K/A
o    The  Company's  historical  consolidated  financial  statements  and  notes
     thereto for the three months ended March 31, 2003 included in the Company's
     Report on Form 10-Q.
o    The historical financial  statements and notes thereto of ISI  included  as
     Exhibit 99.1 to this Current Report of Form 8-K/A.

The  following  unaudited  Pro  Forma  consolidated   financial  statements  are
preliminary and subject to change based on finalization of the other  applicable
post-closing  adjustments including the finalization of the fair values assigned
to acquired assets and assumed obligations. Results are not intended to indicate
what operations  would have been if transactions  would have been consummated on
these dates or a reflection of future operations.








                         Hemispherx Biopharma, Inc. and
                                  Subsidiaries
            Unaudited Pro Forma Consolidated Statement of Operations
                      Year ended December 31, 2002                                                    (4)          PRO FORMA
                  (in thousands, except per share data)                (3)                         PRO FORMA       AS FURTHER
                                                                    PRO FORMA     PRO FORMA         FURTHER         ADJUSTED
                                    (1)              (2)           ADJUSTMENTS   AS ADJUSTED      ADJUSTMENTS          FOR
                                 HEMISPHERX       INTERFERON        FOR FIRST     FOR FIRST       FOR SECOND         SECOND
                               BIOPHARMA, INC.   SCIENCES, INC.       ASSET         ASSET            ASSET            ASSET
                              AND SUBSIDIARIES   AND SUBSIDIARY    ACQUISITION   ACQUISITION      ACQUISITION      ACQUISITION

                                                                                                     
                               ----------------  --------------    -----------   -----------      -----------      -----------
                                    2002             2002
                                    ----             ----

Revenues:

Sales of product                 $       -        $     1,926      $              $  1,926        $                  $  1,926

Clinical treatment programs             341                                            341                                341

License fee income                      563                                            563                                563

                               ----------------- ----------------- ------------  -------------- --------------    ----------------

                                        904             1,926           -            2,830              -               2,830
                               ----------------- ----------------- ------------  -------------- --------------    ----------------
Costs and expenses:

Costs of goods sold/idle
Production costs                          -             1,482            (37)(a)     1,445              60(e)           1,505

Research and development              4,946             1,514            (39)(a)     6,421              7(e)            6,428

General and administrative            2,015             1,818            (34)(a)     3,915              6(e)            3,921
                                                                         116 (c)

                              ------------------ ----------------- ------------- -------------- --------------    ----------------

Total cost and expenses               6,961             4,814              6        11,781             73              11,854
                              ------------------ ----------------- ------------- -------------- --------------    ----------------

Interest and other income               103                 7             (7)(a)       103                                103

Interest and related expenses                            (386)           386 (a)    (1,551)        (1,609)(d)          (3,160)
                                                                      (1,551)(b)

Investments in
unconsolidated affiliates            (1,470)                                        (1,470)                            (1,470)
Gain on sale of state net
operating loss carryovers                                 528           (528)(a)         -                                  -


                              ------------------ ----------------- ------------- -------------- --------------    ----------------
Net loss                       $     (7,424)      $    (2,739)    $   (1,706)    $ (11,869)    $   (1,682)          $ (13,551)
                              ------------------ ----------------- ------------- -------------- --------------    ----------------

Basic and diluted loss per
share                          $      (0.23)                                     $   (0.36)                          $  (0.40)

                              ------------------                                 --------------                   ----------------
Basic and diluted weighted
Average common shares
outstanding
                                      32,086                             487         32,573          1,069              33,642
                              ------------------                  -------------- -------------- --------------    ----------------


See accompanying notes to consolidated statement of operations





                           NOTES TO UNAUDITED PROFORMA
                      CONSOLIDATED STATEMENT OF OPERATIONS

The  following  notes  describe the column  headings in the  unaudited pro forma
consolidated  statement of operations  and the pro forma  adjustments  that have
been made to this statement:

     (1) Reflects the audited consolidated historical statement of operations of
Hemispherx  Biopharma,  Inc. and  subsidiaries  for the year ended  December 31,
2002.

     (2) Reflects the audited  consolidated  historical  statement of operations
for ISI for the year ended December 31, 2002.

     (3) Reflects pro forma  adjustments  relating to the first  acquisition  of
certain assets of ISI and the related funding as follows:

(a)  Adjustments  to reflect the  recording of costs related to sales of product
     by ISI  where  values  were  reduced  to zero in years  prior to 2002,  the
     elimination  of  ISI's  net  interest  expense,  the  elimination  of ISI's
     depreciation,  and the  elimination  of a gain on the sale of a tax loss by
     ISI as follows:


               Inventory                              $(287)

               Interest  expense-net                    379

               Depreciation                             397

               Sale of state net  operating  loss
                carryover                              (528)
                                                       -----

               Total                                 $(  39)
                                                       ----


(b)  Increase in interest expense resulting from the issuance of $3.1 million of
     6% senior convertible debentures. Interest expense is inclusive of deferred
     interest  charges  resulting  from the Company  recording debt discounts of
     $2.1  million  in  recognition  of  fair  values  of  detachable  warrants,
     contingent  conversion  features,  original  issued discount and settlement
     costs recorded in connection with the debenture offering.

(c)  Increase  in  general  and  administrative  costs  of  resulting  from  the
     recognition of 6% royalty charges on the net sales of the acquired  ALFERON
     N injection product.

     (4) Reflects pro forma  adjustments  relating to the second  acquisition of
certain asset of ISI and the related funding as follows:

(d)  Increase in interest  expense  resulting from the issuance of an additional
     $1.6 million 6% senior  convertible  debentures and  additional  detachable
     warrants to purchase  1,000,000 shares of common stock at $2.40 per share .
     Interest expense is inclusive of deferred  interest charges  resulting from
     the Company  recording of additional debt discounts of  approximately $ 2.8
     million in  recognition of fair values of additional  detachable  warrants,
     contingent  conversion  features,  original  issued discount and additional
     settlement costs recorded in connection with the debenture offering.

(e)  Adjustments reflect  depreciation expense relating to the acquired building
     as result of the second acquisition of certain assets of ISI.








              Hemispherx Biopharma, Inc. and Subsidiaries
       Unaudited Pro Forma Consolidated Statement of Operations
                Three Months ended March 31, 2003                                                (4)       PRO FORMA
              (in thousands, except per share data)                    (3)                    PRO FORMA    AS FURTHER
                                                                    PRO FORMA      PRO FORMA   FURTHER      ADJUSTED
                                         (1)             (2)       ADJUSTMENTS   AS ADJUSTED ADJUSTMENTS      FOR
                                     HEMISPHERX       INTERFERON    FOR FIRST     FOR FIRST  FOR SECOND     SECOND
                                   BIOPHARMA, INC.  SCIENCES, INC.    ASSET         ASSET       ASSET        ASSET
                                  AND SUBSIDIARIES  AND SUBSIDIARY ACQUISITION   ACQUISITION ACQUISITION  ACQUISITION

                                                                                            
                                  ----------------  -------------- -----------   ----------- -----------  -----------
                                        2003             2003
                                        ----             ----

Revenues:

Sales of product                          $19           $ 242           $            $ 261      $              $ 261
Clinical treatment programs                47                                           47                        47


                                  ----------------- -------------- -----------   ----------- -----------  ------------
                                           66             242                          308                       308
                                  ----------------- -------------- -----------   ----------- -----------  ------------
Costs and expenses:
Costs of goods sold/idle
Production costs                          118             267          47  (a)         432         15 (e)        447
Research and development                  873             190          (7) (a)       1,056          2 (e)      1,058
General and administrative                667             266          (7) (a)         941          2 (e)        943
                                                                       15  (c)

                                  ----------------- -------------- ------------  ----------- -----------  ------------
Total cost and expenses                 1,658             723          48            2,429         19          2,448
                                  ----------------- -------------- ------------  ----------- -----------  ------------

Interest and other income                  50                                           50                        50
Interest and related expenses             (75)            (33)         33  (a)        (386)      (399) (d)      (785)
                                                                     (311) (b)
Service fee income                                        115        (115) (a)
Other income                                                6          (6) (a)
Bulk sale of Alferon                                    1,164      (1,164) (a)
inventory


                                  ------------------ ------------- ------------  ----------- -----------   ------------
Net loss                             $ (1,617)          $ 771    $ (1,611)        $ (2,457)    $ (418)       $ (2,875)
                                  ------------------ ------------- ------------  ----------- -----------   ------------

Basic and diluted loss per             $ (.05)                                      $ (.07)                   $ (.09)
share
                                  ------------------                             -----------               ------------
Basic and diluted weighted
Average common shares
outstanding
                                       32,394                          487           32,881      1,069         33,950
                                  ------------------               ------------  ----------- -----------   ------------


See accompanying notes to consolidated statement of operations





                           NOTES TO UNAUDITED PROFORMA
                      CONSOLIDATED STATEMENT OF OPERATIONS



The  following  notes  describe the column  headings in the  unaudited pro forma
consolidated  statement of operations  and the pro forma  adjustments  that have
been made to this statement:

     (1) Reflects the unaudited consolidated  historical statement of operations
of Hemispherx  Biopharma,  Inc.and subsidiaries for the three months ended March
31, 2003.

     (2) Reflects the unaudited consolidated  historical statement of operations
for ISI for the period ended March 11, 2003.

     (3) Reflects pro forma  adjustments  relating to the first  acquisition  of
certain assets of ISI and the related funding as follows:

(a)  Adjustments  to reflect the  recording of costs related to sales of product
     by ISI  where  values  were  reduced  to zero in years  prior to 2002,  the
     elimination  of  ISI's  net  interest  expense,  the  elimination  of ISI's
     depreciation  , and the  elimination  of a gain and  service  fee income in
     connection with the sale of the Alferon business as follows:


            Inventory                                $(109)

            Interest  expense                            33

            Depreciation                                 76

            Service fee income                        (115)

            Other income                                (6)

            Bulk sale of Alferon inventory          (1,164)
                                                   --------
            Total                                  $(1,285)
                                                   --------

(b)  Increase in interest expense resulting from the issuance of $3.1 million of
     6% senior convertible debentures. Interest expense is inclusive of deferred
     interest  charges  resulting  from the Company  recording debt discounts of
     $2.1  million  in  recognition  of  fair  values  of  detachable  warrants,
     contingent  conversion features and original issued discount and settlement
     costs recorded in connection with the debenture offering.

(c)  Increase in general and administrative costs resulting from the recognition
     of 6% royalty charges on the net sales of the acquired  ALFERON N injection
     product.

     (4) Reflects pro forma  adjustments  relating to the second  acquisition of
certain asset of ISI and the related funding as follows:

(d)  Increase in interest  expense  resulting from the issuance of an additional
     $1.6 million 6% senior  convertible  debentures and additional  warrants to
     purchase  1,000,000  shares of common  stock at $2.40 per  share.  Interest
     expense is  inclusive  of  deferred  interest  charges  resulting  from the
     Company  recording  of  additional  debt  discounts of  approximately  $2.8
     million in  recognition of fair values of additional  detachable  warrants,
     contingent  conversion  features,  original  issued discount and additional
     settlement costs recorded in connection with the debenture offering.

(e)  Adjustments reflect  depreciation expense relating to the acquired building
     as result of the second acquisition of certain assets of ISI.







    Hemispherx Biopharma, Inc. and Subsidiaries                      PRO FORMA
Unaudited Pro Forma Consolidated Balance Sheet             (2)          AS
             March 31, 2003                (1)          PRO FORMA     ADJUSTED
             (in thousands)             HEMISPHERX     ADJUSTMENTS      FOR
                                        BIOPHARMA,     FOR SECOND      SECOND
                                         INC. AND         ASSET        ASSET
                                       SUBSIDIARIES    ACQUISITION  ACQUISITION
                                       -------------   ------------ -----------
                 ASSETS
Current Assets:
    Cash and cash equivalents               $ 3,409        $ 1,471       $4,880
    Other receivables                         1,519                       1,519
    Inventories net of reserves               1,829                       1,829
    Prepaid and other current assets            142                         142
                                      --------------   ------------  ----------
    Total current assets                      6,899          1,471        8,370
                                      --------------   ------------  ----------
    Property, plant and equipment,net           133          2,189        2,322
    Patent and trademark rights, net            978                         978
    Investments in unconsolidated
    affiliates                                  408                         408
    Deferred financing costs                    260             79          339
    Other assets                                 51                          51
                                      --------------   ------------  ----------
    Total assets                             $8,729         $3,739      $12,468
                                      ==============   ============  ==========
             LIABILITIES
Current liabilities:
    Accounts payable                         $1,588          $ 522       $2,110
    Accrued expenses                            668                         668
    Current portion of long term
    debt                                        570           (570)           -
                                      --------------   ------------  ----------
    Total current liabilities                 2,826            (48)       2,778
                                      --------------   ------------  ----------
Long term debt-net of current
portion                                         638         (638)            -

Redeemable common stock                         675           675         1,350
Stockholders' equity :
    Common stock                                 33             1            34
    Additional paid-in capital              108,964         3,749       112,713
    Accumulated deficit                   (100,691)                    (100,691)
    Treasury stock                          (3,716)                      (3,716)
                                      --------------   -----------   ----------

    Total stockholders' equity                4,590         3,750         8,340
                                      --------------   -----------   ---------
    Total liabilities and
    stockholders' equity                    $ 8,729       $ 3,739       $12,468
                                      ==============   ===========   ==========

See accompanying notes to consolidated balance sheet





                           NOTES TO UNAUDITED PROFORMA
                           CONSOLIDATED BALANCE SHEET



The following  notes  describe the column  headings in the  unaudited  pro-forma
consolidated  balance sheet and the pro forma adjustments that have been made to
this balance sheet:

     (1)  Reflects  the  unaudited   consolidated   historic  balance  sheet  of
Hemispherx Biopharma Inc. and subsidiaries as of March 31, 2003.


     (2) Reflects pro forma  adjustments  for the second  acquisition of certain
assets  of  ISI  of  approximately  $2.2  million,  the  assumption  of  certain
obligations,  and the related  financing,  inclusive  of the  proceeds  received
totaling  approximately  $1.5 million,  from the issuance of an additional  $1.6
million of 6% Senior Convertible  Debentures,  additional warrants to acquire an
aggregate of 1,000,000  shares of common stock, the recording of additional debt
discounts  of  approximately  $2.8  million  in  recognition  of fair  values of
additional detachable warrants,  contingent conversion features, original issued
discount  and  settlement  costs  recorded  in  connection  with  the  debenture
offering,  resulting in a net adjustment of  approximately  $1.2 million,  which
effectively  reduced  the  carrying  value  of the  debt to zero  and  increased
additional paid in capital by approximately $3.8 million. Portions of the common
shares,  totaling  approximately  $.7 million  issued to ISI were  redeemable in
nature and are reflected as such.


     As a result of the agreements, the following table summarizes the estimated
fair  values of the assets and  liabilities  assumed  at the  acquisition  date.
                             (AMOUNTS IN THOUSANDS)


Second Acquisition
-------------------

Building                                       $2,189
Fair Value of liabilities Assumed                (522)
                                              -------
Fair Value of Common Shares
Issued                                         $1,667
                                              =======






(a)      Exhibits



Exhibit No.                   Exhibit

99.1      The financials statements of Interferon Sciences,  Inc. as of December
          31, 2002 and 2001 and for the three years ended December 31, 2002.









                                    SIGNATURE


Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


                                           Hemispherx Biopharma, Inc.


                                           By:
                                            /s/ William A. Carter
                                           ----------------------------------
August 13 , 2003           William A. Carter, M.D., President