UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934



                                  ZONAGEN, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)



                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)



                                    98975L108
--------------------------------------------------------------------------------
                                 (CUSIP Number)



                                 APRIL 12, 2005
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|  Rule 13d-1(b)

|X|  Rule 13d-1(c)

|_|  Rule 13d-1(d)

------------------
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).




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CUSIP No.                             13G                Page 2 of 9 Pages
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    1.    NAMES OF REPORTING PERSONS

          Great Point Partners, LLC

    2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

          (a)   |_|

          (b)   |_|

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    3.    SEC USE ONLY


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    4.    CITIZENSHIP OR PLACE OF ORGANIZATION

          USA

      NUMBER OF SHARES         5.    SOLE VOTING POWER
        BENEFICIALLY 
       OWNED BY EACH           6.    SHARED VOTING POWER
      REPORTING PERSON                                                510,500
            WITH             
                               7.    SOLE DISPOSITIVE POWER  
                                                             
                               8.    SHARED DISPOSITIVE POWER
                                                                      510,500

    9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     510,500

   10.    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
          SHARES (See Instructions)                                         |_|

   11.    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     5.08%

   12.    TYPE OF REPORTING PERSON (See Instructions)

                     OO





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CUSIP No.                             13G                Page 3 of 9 Pages
----------------------                                  ------------------------



    1.    NAMES OF REPORTING PERSONS

          Dr. Jeffrey R. Jay, M.D.

    2.    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

          (a)   |_|

          (b)   |_|

--------------------------------------------------------------------------------
    3.    SEC USE ONLY


--------------------------------------------------------------------------------

    4.    CITIZENSHIP OR PLACE OF ORGANIZATION

          USA

      NUMBER OF SHARES         5.    SOLE VOTING POWER                      0
        BENEFICIALLY 
       OWNED BY EACH           6.    SHARED VOTING POWER
      REPORTING PERSON                                                510,500
            WITH             
                               7.    SOLE DISPOSITIVE POWER  
                                                                            0
                               8.    SHARED DISPOSITIVE POWER
                                                                      510,500

    9.    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     510,500

   10.    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN  
          SHARES (See Instructions)                                         |_|

   11.    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     5.08%

   12.    TYPE OF REPORTING PERSON (See Instructions)

                     IN





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CUSIP No.                             13G                Page 4 of 9 Pages
----------------------                                  ------------------------


     ITEM 1.

                    (a)      Name of Issuer

                             Zonagen, Inc.

                    (b)      Address of Issuer's Principal Executive Offices

                             2408 Timberloch Place, Suite B-1
                             The Woodlands, TX 77380

     ITEM 2.

                    (a)      Name of Person Filing

                                      Great Point Partners, LLC
                                      Dr. Jeffrey M. Jay, M.D.

                    The Reporting Persons have entered into a Joint Filing
                    Agreement, dated April 21, 2005, a copy of which is filed
                    with this Schedule 13G as Exhibit A, pursuant to which the
                    Reporting Persons have agreed to file this statement jointly
                    in accordance with the provisions of Rule 13d-1(k)(1) under
                    the Act.

                    (b)      Address of Principal Business Office, or if none,
                             Residence

                             The address of the principal business office of 
                             each of the Reporting Persons is

                                      2 Pickwick Plaza
                                      Suite 450
                                      Greenwich, CT  06830

                    (c)      Citizenship

                    Great Point Partners, LLC is a limited liability company 
                    organized under the laws of the State of Delaware.  Dr. 
                    Jeffrey M. Jay, M.D. is a citizen of the United States.

                    (d)      Title of Class of Securities

                             Common Stock

                    (e)      CUSIP Number

                             98975L108

     ITEM 3.        IF THIS STATEMENT IS FILED PURSUANT TO SS.240.13d-1(b) OR
                    240.13d.2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

                             Not Applicable.

                    (a)   |_|   Broker or dealer registered under Section 15 of
                                the Act (15 U.S.C. 78o)

                    (b)   |_|   Bank as defined in Section 3(a)(6) of the Act
                                (15 U.S.C. 78c).

                    (c)   |_|   Insurance company as defined in Section 3(a)(19)
                                of the Act (15. U.S.C. 78c).

                    (d)   |_|   Investment Company registered under Section 8 of
                                the Investment Company Act of 1940 (15 U.S.C. 
                                80a-8).



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CUSIP No.                             13G                Page 5 of 9 Pages
----------------------                                  ------------------------


                    (e)   |_|   An investment adviser in accordance with
                                ss.240.13d-1(b)(1)(ii)(E).
                                
                    (f)   |_|   An employee benefit plan or endowment fund in
                                accordance with ss.240.13d-1(b)(1)(ii)(F).
                                
                    (g)   |_|   A parent holding company or control person in
                                accordance with ss.240.13d-1(b)(1)(ii)(G).
                                
                    (h)   |_|   A savings associations as defined in Section
                                3(b) of the Federal Deposit Insurance Act (12
                                U.S.C. 1813).
                          
                    (i)   |_|   A church plan that is excluded from the
                                definition of an investment company under
                                Section 3(c)(14) of the Investment Company Act
                                of 1940 (15 U.S.C. 80a-3).

                    (j)   |_|   Group, in accordance with 
                                ss.240.13d-1(b)(1)(ii)(J).









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CUSIP No.                             13G                Page 6 of 9 Pages
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     ITEM 4.        OWNERSHIP

                    Great Point Partners, LLC ("Great Point") is the investment
                    manager of Biomedical Value Fund, L.P. ("BVF"), and by
                    virtue of such status may be deemed to be the beneficial
                    owner of the 290,985 shares of Common Stock of the Issuer
                    owned by BVF (the "BVF Shares"). Dr. Jeffrey R. Jay, M.D.
                    ("Dr. Jay"), as senior managing member of Great Point, has
                    voting and investment power with respect to the BVF Shares,
                    and therefore may be deemed to be the beneficial owner of
                    the BVF Shares.

                    Great Point is the investment manager of Biomedical Offshore
                    Value Fund, Ltd. ("BOVF"), and by virtue of such status may
                    be deemed to be the beneficial owner of the 219,515 shares
                    of Common Stock of the Issuer owned by BOVF (the "BOVF
                    Shares"). Dr. Jay, as senior managing member of Great Point,
                    has voting and investment power with respect to the BOVF
                    Shares, and therefore may be deemed to be the beneficial
                    owner of the BOVF Shares.

                    Provide the following information regarding the aggregate
                    number and percentage of the class of securities of the
                    issuer identified in Item 1.

                    1.       GREAT POINT PARTNERS, LLC

                    (a)      Amount beneficially owned: 510,500.

                    (b)      Percent of class: 5.08%.

                    (c)      Number of shares as to which the person has:

                             (i)    Sole power to vote or to direct the vote: 
                                    - 0 -

                             (ii)   Shared power to vote or to direct the vote:
                                    510,500.

                             (iii)  Sole power to dispose or to direct the 
                                    disposition of:  - 0 -.

                             (iv)   Shared power to dispose or to direct the
                                    disposition of:  510,500.

                    2.       DR. JEFFREY R. JAY, M.D.

                    (a)      Amount beneficially owned: 510,500

                    (b)      Percent of class: 5.08%.

                    (c)      Number of shares as to which the person has:

                             (i)    Sole power to vote or to direct the vote: 0.

                             (ii)   Shared power to vote or to direct the vote:
                                    510,500.

                             (iii)  Sole power to dispose or to direct the
                                    disposition of: 0.

                             (iv)   Shared power to dispose or to direct the
                                    disposition of: 510,500.

     ITEM 5.        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                    Not Applicable.

     ITEM 6.        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER 
                    PERSON:

                    Not Applicable.



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CUSIP No.                             13G                Page 7 of 9 Pages
----------------------                                  ------------------------


     ITEM 7.        IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH 
                    ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT 
                    HOLDING COMPANY
     
                    Not Applicable.
     
     ITEM 8.        IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP
     
                    Not Applicable.
     
     ITEM 9.        NOTICE OF DISSOLUTION OF GROUP
     
                    Not Applicable.
     
     ITEM 10.       CERTIFICATION

   
     By signing below I certify that, to the best of my knowledge and belief,
     the securities referred to above were not acquired and are not held for the
     purpose of or with the effect of changing or influencing the control of the
     issuer of the securities and were not acquired and are not held in
     connection with or as participant in any transaction having that purpose or
     effect.





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CUSIP No.                             13G                Page 8 of 9 Pages
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                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date:  April 21, 2005

                                    GREAT POINT PARTNERS, LLC

                                    By:  /s/ DR. JEFFREY R. JAY, M.D.           
                                         ---------------------------------------
                                         Dr. Jeffrey R. Jay, M.D.,
                                           as senior managing member

                                    /s/ DR. JEFFREY R. JAY, M.D.                
                                    --------------------------------------------
                                    DR. JEFFREY R. JAY, M.D.







                                                                       EXHIBIT A

              AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G

The undersigned hereby agree as follows:

         (i) Each of them is individually eligible to use the Schedule 13G to
which this Exhibit is attached, and such Schedule 13G is filed on behalf of each
of them; and

         (ii) Each of them is responsible for the timely filing of such Schedule
13G and any amendments thereto, and for the completeness and accuracy of the
information concerning such person contained therein; but none of them is
responsible for the completeness or accuracy of the information concerning the
other persons making the filing, unless such person knows or has reason to
believe that such information is inaccurate.

Date:  April 21, 2005

                                    GREAT POINT PARTNERS, LLC

                                    By:  /s/ DR. JEFFREY R. JAY, M.D.           
                                         ---------------------------------------
                                         Dr. Jeffrey R. Jay, M.D.,
                                           as senior managing member


                                    /s/ DR. JEFFREY R. JAY, M.D.                
                                    --------------------------------------------
                                    DR. JEFFREY R. JAY, M.D.