Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  La Barge Joseph
 2. Date of Event Requiring Statement (Month/Day/Year)
05/02/2016		 3. Issuer Name and Ticker or Trading Symbol
Spark Therapeutics, Inc. [ONCE]
(Last)
(First)
(Middle)
3737 MARKET STREET, SUITE 1300		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
See remarks
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

PHILADELPHIA, PA 19104		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 5,325 (1) (2)
D
 
Common Stock 200
I
Held by Reporting Person's immediate family members

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (3) 06/09/2024 Common Stock 25,383 $ 3.45 D  
Employee Stock Option (right to buy)   (4) 07/01/2024 Common Stock 31,929 $ 3.45 D  
Employee Stock Option (right to buy)   (5) 03/15/2025 Common Stock 45,000 $ 68.45 D  
Employee Stock Option (right to buy)   (6) 01/04/2026 Common Stock 45,000 $ 40.44 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
La Barge Joseph
3737 MARKET STREET
SUITE 1300
PHILADELPHIA, PA 19104		       See remarks  

Signatures

/s/ Joseph W. La Barge 05/04/2016
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) 4,825 shares were granted on December 11, 2013 and 25% vested on December 11, 2014 and the remainder vests in equal quarterly installments over the following three years.
(2) 500 shares were granted on November 4, 2015 and vest upon a performance condition
(3) 25% vested November 11, 2014 and the remainder vests in equal quarterly installments over the following three years.
(4) 25% vested May 24, 2015 and the remainder vests in equal quarterly installments over the following three years.
(5) 25% vested March 16, 2016 and the remainder vests in equal quarterly installments over the following three years.
(6) 25% vested January 5, 2017 and the remainder vests in equal quarterly installments over the following three years.
 
Remarks:
General Counsel and Head of Business Administration

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