Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Children's Hospital of Philadelphia Foundation
   2. Issuer Name and Ticker or Trading Symbol
Spark Therapeutics, Inc. [ONCE] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
3737 MARKET STREET, SUITE 1300		 3. Date of Earliest Transaction (Month/Day/Year)
02/04/2015
(Street)

PHILADELPHIA, PA 19104		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 02/04/2015   C   1,000,000 A (1) 5,943,629 D  
Common Stock 02/04/2015   C   2,795,031 A (2) 8,738,660 D  
Common Stock 02/04/2015   C   61,552 A (3) 8,800,212 D  
Common Stock 02/04/2015   P   100,000 A $ 23 8,900,212 D  

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series A Preferred Stock (1) 02/04/2015   C     1,000,000   (1)   (1) Common Stock 1,000,000 $ 0 0 D  
Series B Preferred Stock (2) 02/04/2015   C     2,795,031   (2)   (2) Common Stock 2,795,031 $ 0 0 D  
Accrued Preferred Stock Dividends (3) 02/04/2015   C     61,552   (3)   (3) Common Stock 61,552 $ 0 0 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Children's Hospital of Philadelphia Foundation
3737 MARKET STREET
SUITE 1300
PHILADELPHIA, PA 19104		     X    

Signatures

 Jeffrey D. Kahn, Attorney-In-Fact for The Children's Hospital of Philadelphia Foundation   02/04/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Shares of Series A Preferred Stock automatically converted into shares of the Common Stock on a one-for-one basis without payment of further consideration upon the closing of the Issuer's initial public offering on February 4, 2015.
(2) Shares of Series B Preferred Stock automatically converted into shares of the Common Stock on a one-for-one basis without payment of further consideration upon the closing of the Issuer's initial public offering on February 4, 2015.
(3) Paid-in-kind dividends declared and paid on the Series A Preferred Stock and Series B Preferred Stock automatically converted into shares of Common Stock on a one-for-one basis without payment of further consideration upon the closing of the issuer's initial public offering on February 4, 2015.

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